Product Information:
Cat. No.: EX-A636 | Purity: >99% |
Chemical structure of MMAE |
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Synonyms | Monomethyl auristatin E |
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Synonyms 2 | SGD-1010 |
CAS No. | 474645-27-7 |
Purity | >99% |
Formula | C39H67N5O7 |
Mol Weight | 717.9786 |
Appearance | Solid powder |
Solubility | DMSO >40mg/mL |
Shelf Life | >2 years if stored properly |
Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Reference: | [1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.
[2]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. |
CoA | CoA of MMAE |
Smiles: | CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C |
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