BDTX-189

Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.


Cat. No.: EX-A4379	Purity: >98%

	Chemical structure of BDTX-189

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	285	In-stock
250mg	450	In-stock
500mg	650	In-stock
1g	1050	In-stock
5g	3500	In-stock
10g	5400	In-stock

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Synonyms	Tuxobertinib
CAS No.	2414572-47-5
Purity	>98%
Formula	C29H29ClN6O4
Mol Weight	561.031
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.
CoA	CoA of BDTX-189

Smiles:	C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O


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