MMAE

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization.


Cat. No.: EX-A636	Purity: >99%

	Chemical structure of MMAE

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	450	In-stock
1g	875	In-stock
5g	Get quote	In-stock
10g	Get quote	In-stock

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Synonyms	Monomethyl auristatin E
Synonyms 2	SGD-1010
CAS No.	474645-27-7
Purity	>99%
Formula	C39H67N5O7
Mol Weight	717.9786
Appearance	Solid powder
Solubility	DMSO >40mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. [2]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
CoA	CoA of MMAE

Smiles:	CC[C@H](C)C([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C


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