SAGE-718

Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.


Cat. No.: EX-A6875	Purity: >98%

	Chemical structure of SAGE-718

For research only, Do not use for Human!

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CAS No.	1629853-48-0
Purity	>98%
Formula	C27H43F3O2
Mol Weight	456.6243
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Beckley, Jacob T et al. “Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.” British journal of pharmacology vol. 181,7 (2024): 1028-1050. doi:10.1111/bph.16235 [2]. Hill, Matthew D et al. “SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.” Journal of medicinal chemistry vol. 65,13 (2022): 9063-9075. doi:10.1021/acs.jmedchem.2c00313
CoA	CoA of SAGE-718

Smiles:	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CC[C@](C(F)(F)F)(C)O)C)(CC4)[H])[H])(CC=C1C[C@@](C)(O)CC2)[H])[H]


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