Lugdunin

Lugdunin is a novel thiazolidine-containing cyclic peptide antibiotic, suppressing growth of species of disease-causing bacteria in that part of the human microbiome.


Cat. No.: EX-A5148	Purity: >98%

	Chemical structure of Lugdunin

For research only, Do not use for Human!

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CAS No.	1989698-37-4
Purity	>98%
Formula	C40H62N8O6S
Mol Weight	783.035
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Saur JS, et al. Distinct Lugdunins from a New Efficient Synthesis and Broad Exploitation of Its MRSA- Antimicrobial Structure. J Med Chem. 2021 Apr 8;64(7):4034-4058. [2]. Heilbronner S, et al. Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential. Clin Microbiol Rev. 2020 Dec 23;34(2):e00205-20. [3]. Krauss S, et al. Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01734-20. [4]. Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730. [5]. Schilling NA, et al. Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. [6]. Milshteyn A, et al. Accessing Bioactive Natural Products from the Human Microbiome. Cell Host Microbe. 2018 Jun 13;23(6):725-736. [7]. Zipperer A, et al. Human commensals producing a novel antibiotic impair pathogen colonization. Nature. 2016 Jul 28;535(7613):511-6.
CoA	CoA of Lugdunin


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