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Product Information:

CB-5339

CB-5339 is a second generation, potent and selective, orally bioavailable, ATP-competitive, small molecule inhibitor of valosin containing protein (VCP)/p97 with IC50 of 9 nM.

Cat. No.: EX-A6139    Purity: >98%
Chemical
Chemical structure of CB-5339


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg450In-stock
250mg750In-stock
500mg1150In-stock
1g1800In-stock
5g5680In-stock
10g7925In-stock


Synonymsp97-IN-1
CAS No.1863952-15-1
Purity>98%
FormulaC24H24N6O
Mol Weight412.487
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Roux, Blandine et al. “Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.” Science translational medicine vol. 13,587 (2021): eabg1168. doi:10.1126/scitranslmed.abg1168

[2]. Fiskus W C, Das K, Mill C P, et al. Efficacy of Vcp/p97 Inhibitor, CB-5339, Alone and in Combinations Against High-Risk AML, Including Those with Genetic Lesion in TP53[J]. Blood, 2022, 140(Supplement 1): 8807-8808.

[3]. Wang X, Wen T, Miao H, et al. Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of colorectal cancer[J]. Bioorganic & Medicinal Chemistry, 2022, 74: 117050.

CoACoA of CB-5339

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