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Product Information:

BMS-986365

BMS-986365 (CC-94676) is a selective heterobifunctional ligand-directed degrader (LDD) targeting the androgen receptor (AR). BMS-986365 (CC-94676) demonstrated significant in vivo potency, degrading AR, inhibiting AR signaling, and inhibiting tumor growth in animal models of advanced prostate cancer.

Cat. No.: EX-A8829    Purity: >98%
Chemical
Chemical structure of BMS-986365


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg750In-stock
250mg1400In-stock
500mg2200In-stock
1g3520In-stock
2g4860In-stock
5gget quoteIn-stock


CAS No.2446928-30-7
Purity>98%
FormulaC41H45F3N8O5S
Mol Weight818.907
Appearancesolid
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Xu S, et al. Abstract ND02: Discovery of BMS-986365, a ligand-directed androgen receptor degrader (AR LDD) with a dual mechanism-of-action and best-in-class potential, for the treatment of advanced prostate cancer[J]. Cancer Research, 2024, 84(7_Supplement): ND02-ND02.

Data SheetData sheet of BMS-986365
CoACoA of BMS-986365
SDSSDS of BMS-986365
Smiles:S=C1N(C(=O)C(C)(C)N1C2=CC(CC)=C(OCCN3C[C@@H](C)N(CC(NC4=CC(NC5C(=O)NC(=O)CC5)=CC=C4)=O)CC3)C=C2)C6=CC(C(F)(F)F)=C(C#N)C=C6

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