ARV-471

ARV-471 (Vepdegestrant) is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. ARV-471 (Vepdegestrant) is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex.


Cat. No.: EX-A5021	Purity: >98%

	Chemical structure of ARV-471

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	650	In-stock
100mg	900	In-stock
200mg	1450	In-stock
250mg	1700	In-stock
1g	4800	In-stock
5g	Get quote	In-stock

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Synonyms	Vepdegestrant
CAS No.	2229711-68-4
Purity	>98%
Formula	C45H49N5O4
Mol Weight	723.9017
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lin X, et al. Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance. Eur J Med Chem. 2020;206:112689. [2]. John J. Flanagan, et al. ARV-471, an oral estrogen receptor PROTAC™ protein degrader for breast cancer. American Association for Cancer Research.2019. 79 (4): P5-04-18. [3]. Schneider, M., Radoux, C.J., Hercules, A. et al. The PROTACtable genome. Nat Rev Drug Discov 20, 789–797 (2021). https://doi.org/10.1038/s41573-021-00245-x.
Data Sheet	Data sheet of ARV-471
CoA	CoA of ARV-471
SDS	SDS of ARV-471


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