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Product Information:

AM-9747

AM-9747 is an MTA cooperative PRMT5 inhibitor. AM-9747 selectively inhibited the proliferation of HCT116 MTAP-deleted cells (IC50 = 0.027 μM).

Cat. No.: EX-A6437    Purity: >98%
Chemical
Chemical structure of AM-9747


For research only, Do not use for Human!

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SynonymsPRMT5-IN-25
CAS No.2691869-82-4
Purity>98%
FormulaC24H21F3N6O
Mol Weight466.4583
Appearancesolid powder
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Brian Belmontes, Antonia Policheni, Siyuan Liu, Katherine Slemmons, Jodi Moriguchi, Hayley Ma, Daniel Aiello, Yajing Yang, Mikkel Vestergaard, Sanne Cowland, Jan Anderson, Ian Sarvary, Nuria Tamayo, Liping Pettus, Susmith Mukund, Leszek Pope, Jennifer R. Allen, Sanne Glad, Matthew Bourbeau, Paul E. Hughes; Abstract 1807: The discovery and preclinical characterization of the MTA cooperative PRMT5 inhibitor AM-9747. Cancer Res 15 June 2022; 82 (12_Supplement): 1807. https://doi.org/10.1158/1538-7445.AM2022-1807. [2]. Jennifer Rebecca Allen, et al. Novel prmt5 inhibitors. WO2021163344A1.
CoACoA of AM-9747

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